allergy to polyethylene glycol, propylene glycol, ethylene & butylene glycols

Links to Documentation of Glycol Allergies

Show These to Your Doctor

If your doc doesn’t believe it’s possible to have an allergy to polyethylene glycol, offer this link to a Danish study published in the journal Clinical and Experimental Allergy by Dr. Emily Cathrine Wenande. She posted the below article in a facebook group you might want to join called Rare Allergy in the U.K. – Polyethylene Glycol

Dr. Wenande writes:

This is an initial step in getting this rare but difficult condition recognised in the medical community at large. The review compiles all published cases of PEG hypersensitivity since 1977 (with many still surfacing at present), describing culprit agents, synonyms, symptoms, allergological testing (with an algorithm), potential immunological mechanisms and risk of cross-reactivity. Feel free to look it over and/or share it with your doctor.

We are very grateful for Dr. Wenande’s research and look forward to hearing more from this powerful ally!

The below link goes to a place where you can rent the article for $6, purchase for cloud storage $12, or purchase for download for $38. It’s quick and easy to sign up. Click on this link, then go to the logo in the upper right corner for Wiley Online Library. (Fees for this article go to Wiley Online Library)
http://www.ncbi.nlm.nih.gov/pubmed/27196817

 Glycol Allergies – Additional Articles:

Here are links additional articles that may help with convincing your doctor that allergies to glycols exist. At the bottom of a couple of them are other sources cited that your doc may want to see. If you find other sources – scientific papers or reports by medical experts, please let me know.
Be sure to check out the new COVID19 Vaccine Info page for recent developments.

Amber

PEG Allergy/PEG Sensitivity

In Journal of Clinical Pharmacology: A Case Series of Allergy to Polyethylene Glycol

American Academy of Allergy, Asthma & Immunology Ask the Expert: Macrogols & PEG

American Academy of Allergy, Asthma & Immunology Ask the Expert: Anaphylaxis & Psyllium

American Academy of Allergy, Asthma & Immunology Ask the Expert: Polyethylene Glycol-Dental

American Academy of Allergy, Asthma & Immunology Ask the Expert: Allergic Reaction Following Colonoscopy

American Academy of Allergy, Asthma & Immunology Ask the Expert: Polyethylene Glycol

Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized

Polyethylene Glycol Is a Cause of IgE-Mediated Anaphylaxis

Polyethylene Glycol: Not Just a Harmless Excipient

Macrogol hypersensitivity reactions during cleansing preparation for colon endoscopy

In American Academy of  Allergy Asthma & Immunology, advice on how to handle a patient with PEG allergy: Ask the Expert: Polyethylene Glycol Allergy

Full text of a 2016 article in Allergy, Asthma & Clinical Immunology, referred to in the above “Ask the Expert” column:
Polyethylene glycol as a cause of anaphylaxis

In American Academy of  Allergy Asthma & Immunology, information on an attempt to desensitize a patient to macrogols, a form of polyethylene glycol:  Ask the Expert: Polyethylene glycol allergy and dental restoration

In Clinical and Experimental Allergy, 2016: Immediate‐type hypersensitivity to polyethylene glycols: a review

In US National Library of Medicine, National Institutes of Health, 2017: Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid

Polyethylene glycol as a cause of anaphylaxis
From: Allergy, Asthma & Clinical Immunology 2016, 12:67

Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid
From Clinical and Translational Allergy, 2017; 7: 2

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
From Angewandte Chemie, International Edition, Vol 49, Issue 36

Polyethylene Glycol: Not just a harmless excipient
From Journal of Allergy & Clinical Immunology, October 03, 2018 (Requires fee or membership to access)

Allergy to Macrogols (Polyethylene Glycol)
From Ask the Expert: American Academy of Allergy Asthma & Immunology, 3/6/2013

Anaphylaxis following a transvaginal ultrasound
From Allergy Asthma and Clinical Immunology 12(1) · December 2016

Two cases of anaphylaxis to macrogol 6000 after ingestion of drug tablets 
From Allergy: European Journal of Allergy and Clinical Immunology Volume 61, Issue 8, August 2006

PG Allergy/PG Sensitivity

Propylene Glycol: An Often Unrecognized Cause of Allergic Contact Dermatitis in Patients Using Topical Corticosteroids
from Skin Therapy Letter, Volume 16 Number 5, May 1, 2011

In Dermatitis, a publication of the American Contact Dermatitis Society: Propylene Glycol named 2018 Allergen of the Year by the American Contact Dermatitis Society

In Dermatitis, Contact Allergy to Propylene Glycol and Cross-Reactions